Plasmin processing of PlGF

نویسندگان

  • Daniel C. Hoffmann
  • Sebastian Willenborg
  • Manuel Koch
  • Daniela Zwolanek
  • Stefan Müller
  • Ann-Kathrin A. Becker
  • Stephanie Metzger
  • Martin Ehrbar
  • Peter Kurschat
  • Martin Hellmich
  • Jeffrey A. Hubbell
  • Sabine A. Eming
  • Sabine Eming
چکیده

1 Department of Dermatology, University of Cologne, Cologne, Germany 2 Center for Biochemistry, Institute for Dental Research and Musculoskeletal Biology, University of Cologne, Cologne, Germany 3 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany 4 Department of Obstetrics, University Hospital Zurich, Switzerland 5 Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Germany 6 Institute for Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland 7 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Performance of Circulating Placental Growth Factor as A Screening Marker for Diagnosis of Ovarian Endometriosis: A Pilot Study

Background The aim of this study is to compare the circulating placental growth factor (PlGF) concentration in women with and without endometrioma to verify the performance of this marker to diagnose the disease. MaterialsAndMethods In this case-control study, thirteen women with histological diagnosis of ovarian endometriosis were compared with women without endometriosis disease. PlGF plasma ...

متن کامل

کلونینگ و بیان پروتئین فاکتور رشد جفتی-1 انسانی (hPLGF-1) در سیستم بیانی Rosetta E.coli

سابقه و هدف: آنژیوژنزیس یا شکل گیری عروق خونی جدید در شرایط فیزیولوژیک و پاتولوژیک مهم ترین عامل رشد و تکثیر سلول ها است. پروتئین PLGFیا فاکتور رشد جفتی یکی از مهم ترین پروتئین ها در تحریک آنژیوژنزیس است. در این پژوهش، ژن PLGF-1 انسانی از بافت جفت جدا شده و پروتئین مورد نظر در سیستم باکتریایی بیان شد. روش بررسی: دراین مطالعه تجربی، ناحیه کد کننده ژن PLGF-1 از بافت جفت انسان توسط پرایمرهای اخ...

متن کامل

Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy.

PURPOSE Proliferative vitreoretinopathy (PVR) is the primary cause of failure of retinal reattachment surgery. Growth factors such as platelet-derived growth factor (PDGF) are strongly associated with PVR. Of the five PDGF family members, PDGF-C predominates in the vitreous of experimental and clinical PVR. PDGF-C is secreted as a latent protein that requires proteolytic processing for activati...

متن کامل

Brain plasmin enhances APP α-cleavage and Aβ degradation and is reduced in Alzheimer’s disease brains

The proteolytic processing of Amyloid Precursor Protein (APP) has been linked to sphingolipid-cholesterol microdomains (rafts). However, the raft proteases that may be involved in APP cleavage have not yet been identified. In this work we present evidence that the protease plasmin is restricted to rafts of cultured hippocampal neurons. We also show that plasmin increases the processing of human...

متن کامل

Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation.

Pro-MMP2 activation is a two-step process resulting in (1) an intermediate 64 kDa form generated by the MT1-MMP activity, and (2) a mature 62 kDa form. Addition of plasminogen to HT1080 cells cultured under various conditions, or to their membrane preparation, induced a complete conversion of the intermediate MMP-2 form to the mature one, and processing of pro-MMP-9. The pro-MMP-2 activation wa...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013